Synthesis and hetero-Michael addition reactions of 2-alkynyl oxazoles and oxazolines.
نویسندگان
چکیده
Stereoselective conjugate additions of alcohols, amines, thiols, and halides to C(2)-alkynyl oxazoles and oxazolines provide a versatile entry to heterocyclic building blocks.
منابع مشابه
The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions.
A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 3 1 شماره
صفحات -
تاریخ انتشار 2005